DigiBioMarC™ (DBM) Fatigue is designed as a low burden virtual tool to exquisitely capture key longitudinal biometric data from trial participants. This data is used to rapidly discern troubling trends before they lead to symptom development and safety concerns that may cause trial drop out. Data is shared with clinical trial teams in real time so they are aware of possible safety and retention concerns and can act quickly to prevent poor outcomes that currently increase trial costs and undermine efficacy. The application uses HealthKit and Apples ResearchKit library to conduct clinical trials.